Wei Guo

Assistant Professor - Meat Science & Muscle Biology




Office Location

1933 Observatory Dr
2112 Meat Science & Animal Biologics Discovery Building
Madison, WI 53706

Wei Guo is an Assistant Professor in the Meat Science and Animal Biologics Discovery program (MSABD) at the Department of Animal and Dairy Science.  

Guo’s research interest is focused on posttranscriptional regulation in striated muscle (heart and skeletal muscles) development, growth, regeneration, metabolism as well as diseases using both in vitro and in vivo approaches. His other research focus is to understand the impact of maternal environmental changes on fetal prenatal and postnatal development (Fetal or Developmental Programming) using large animals as models. He is also interested in discovering new bioactive molecules or peptides from animal co-products benefiting the animal industry and human health. He has published over 47 research and review articles as well as 3 book chapters. He is currently supported by an NIH grant, USDA-NIFA and the American Heart Association (AHA) Foundation award 

He received his Ph.D. from China Agricultural University and then moved to UW-Madison for his first postdoc training in the muscle biology lab and second postdoc training in nutritional science. Prior to coming to UW-Madison as a tenure-track faculty position, he was a faculty member at the University of Wyoming. 

Selected Peer-Reviewed Articles

Zhang Y, Gregorich ZR, Wang Y, Braz CU, Zhang J, Liu Y, Liu P, Shen J, Aori N, Hacker TA, Granzier H, Guo W. Disruption of the nuclear localization signal in RBM20 is
causative in dilated cardiomyopathy. JCI Insight. 2023 Jul 10;8(13):e170001. doi:
10.1172/jci.insight.170001. PMID: 37219949; PMCID: PMC10371347. (Highlighted in the Editor’s Picks; https://insight.jci.org/this-month/2023/8)

Zhang Y, Wang C, Sun M, Jin Y, Braz CU, Khatib H, Hacker TA, Liss M, Gotthardt M, Granzier H, Ge Y, Guo W. RBM20 phosphorylation and its role in nucleocytoplasmic transport and cardiac pathogenesis. FASEB J.2022 May;36(5):e22302. PubMed PMID: 35394688;

Larson, Eli J., Gregorich, Zachery R., Zhang, Yanghai, Li, Brad H., Aballo, Timothy J., Melby, Jake A., Ge, Ying and Guo, Wei. ablation is associated with changes in the expression of titin-interacting and metabolic proteins. Mol. Omics, 2022, 18, 627-634

Sun, M.; Jin, Y.; Zhang, Y.; Gregorich, Z.R.; Ren, J.; Ge, Y.; Guo, W. SR Protein Kinases Regulate the Splicing of Cardiomyopathy-Relevant Genes via Phosphorylation of the RSRSP
Stretch in RBM20. Genes. 2022, 13, 1526. https://doi.org/10.3390/genes13091526

Liu Y, Ding Q, Guo W. Life Course Impact of Glucocorticoids During Pregnancy on Muscle Development and Function. Front. Anim. Sci. 2021; 2: 83-89; DOI: 10.3389/fanim.2021.788930.

Wang C, Zhang Y, Methawasin M, Braz CU, Gao-Hu J, Yang B, Strom J, Gohlke J, Hacker T, Khatib H, Granzier H, Guo W. RBM20S639Gmutation is a high genetic risk factor for premature death through RNA-protein condensates. J Mol Cell Cardiol. 2022; 165:115-129. PMID: 35041844.

Liu Y, Ding Q, Halderson, SJ, Arriola Apelo SI, Jones AK, Pillai SM, Hoffman ML, Reed SA, Govoni, KE, Zinn SA, Guo W. Maternal overnutrition during gestation in sheep alters autophagy associated pathways in offspring heart. Front. Genet. 2022, 12:742704. PMID:

Wei Guo, Chaoqun Zhu, Zhiyong Yin, Yanghai Zhang, Chunyan Wang, Andrea Sanchez Walk, Ying-Hsi Lin, Timothy A. McKinsey, Kathleen C. Woulfe, Jun Ren, and Herbert G.
Chew, Jr. The Ryanodine Receptor Stabilizer S107 Ameliorates Contractility of Adult Rbm20 Knockout Rat Cardiomyocytes. Physiol Rep. 2021, 9(17): e15011. PMID: 34523360

Maimaiti R, Zhu CQ, Zhang YH, Ding QY, Guo W. RBM20-mediated pre-mRNA splicing has muscle-specificity and differential hormonal responses between muscles and in muscle cell cultures. Int. J. Mol. Sci. 2021, 22(6), 2928; https://doi.org/10.3390/ijms22062928

Mohammadabadi M. Bordbar F, Jensen J, Du M, Guo W. Key Genes Regulating Skeletal Muscle Development and Growth in Farm Animals. Animals, 2021, 11, 835. https://doi.org/10.3390/ani11030835

Jay W Schneider, Saji Oommen, Muhammad Y Qureshi, Sean C Goetsch, David R Pease, Rhianna S Sundsbak, Wei Guo, Mingming Sun, Han Sun, Hidehito Kuroyanagi, et al. A ribonucleoprotein-granule pathway to heart failure in human RBM20 cardiomyopathy gene-edited pigs. Nature Medicine. 2020; 26(11): 1788-1800.

Farhad Bordbar, Just Jensen, Min Du, Abeid Adam, Wei Guo, Lingyang Xu, Huijiang Gao, Lupei Zhang, Junya Li. Identification and validation of a novel candidate gene regulating net meat weight in Simmental beef cattle based on imputed next-generation sequencing. Cell Proliferation. 2020; 53(9): e12870. PMID: 32722873

Zhi Li, Xiao-Lin Wu, Wei Guo, Jun He, Hao Li, Guilherme J. M. Rosa, Daniel Gianola, Richard G. Tait Jr., Jamie Parham, John Genho, Tom Schultz, Stewart Bauck. Estimation of
genomic breed composition of individual animals in composite beef cattle. Animal Genetics. 2020. 51(3): 457-460.

Hanfang Cai, Chaoqun Zhu, Zhilong Chen, Rexiati Maimaiti, Mingming Sun, Richard J. McCormick, Xianyong Lan, Hong Chen and Wei Guo. Angiotensin II influences pre-mRNA splicing regulation by enhancing RBM20 transcription through activation of the MAPK/ELK1 signaling pathway. Int. J Mol. Sci. 2019. 20(20): E5090. PMID: 31614708.  

Qiurong Wang, Chaoqun Zhu., Mingming Sun., Rexiati Maimaiti., Stephen P. Ford, Peter W. Nathanielsz, Jun Ren and Wei Guo.  Maternal obesity impairs fetal cardiomyocytes contractile function in sheep. FASEB J. 2019; 33(2): 2587-2598. PMID: 30289749.  

Selected Book Chapters

Guo Wei and Greaser, M.L. 2022. “Muscle Structure, Proteins and Meat Quality” in “New aspects of meat quality-from genes to ethics”, 2ed. Peter Purslow, Elsevier, Philadelphia,
PA, In Press

Greaser, M.L. and Guo Wei. 2011. “Post-mortem Muscle Chemistry” In: “Handbook of Meat and Meat Processing, Second Edition”, ed. YH Hui, CRC Press, Boca Raton, FL, pp70-78. 

Greaser, M.L. and Guo Wei. 2014. “Proteins” In “Handbook of Muscle Foods Analysis, Second Edition”, ed, Leo M.L.Nollet, Fidel Toldra, CRC Press, Boca Raton, FL, PP357-368 

Guo Wei and Greaser, M.L. 2016. “Muscle Structure, Proteins and Meat Quality” in “New aspects of meat quality-from genes to ethics”, ed. Peter Purslow, Elsevier, Philadelphia, PA, PP13-32 

Undergraduate Courses

An Sci 336 – Animal Growth & Development (3 credits, Fall)
Course description: Covers growth and development of an animal from a single cell to an organism and factors such as nutrition, hormone, genetics and gut microbials influencing growth
and development in both cell and tissue levels. Includes the molecular and cellular basis of prenatal and postnatal growth and development. Focuses on development and growth of tissues including muscle, adipose, connective, mammary, and bone tissues that are associated with animal production. Also includes the use of growth promotants in livestock to improve growth performance and increase the quality of carcasses and animal production.
Requirements: Zoology 151 and 152 or Zoology 101 and 102.

Topic editor for a Research Topic on “the effect of muscle pathogenesis on
avian physiology, animal welfare, and quality of muscle as a food” for the
Journal of Frontier in Physiology. 2023

Faculty Senate representing faculties at the Department of Animal and Dairy
Sciences. 2023-present

Co-organizer for the 1st ISHR-ACRE pre-conference in Madison, WI. 2023

Co-organizer for the 1st Vascular Biology Retreat for the CAAC in Madison,
WI. 2023

Committee member for Research and Graduate Education Committee. 2020-

Search Committee for Lab manager position of Meat Science and Animal
Biologics Discovery (MSABD) program. 2021-2022

Review Editor, Avian Physiology in Frontiers in Physiology, 2022-present

Guest Editor for a Special Issue titled “Genetics and Mechanistic Basis of
cardiomyopathies” for journal Genes. 2022.

Editorial Board Member, Journal Molecular Medicine Reports. 2021-present

Local organizing committee member for International Society of Heart
Research (ISHR)-North American Section (NAS) scientific conference. 2022

Secretary and Chair for NC 1184 Multi-state meeting. 2021-2022

Organizing committee member for Global Summit on Animal Science and
Veterinary Medicine (ASVM2020), Toyota, Japan. 2020

Co-chair for symposium 10: HFpEF at 40th Annual Meeting of the
International Society of Heart Research (ISHR)-North American Section (NAS)
in Denver, CO. 2020

Session co-chair at the 5th NIH IDeA Western Regional Conference, Jackson, WY. 2017.

Grant reviewers for NIH, AHA, NASA and other funding agencies. 2015-

2022 – Nominee of the Elton D. and Carrie R. Aberle Faculty Fellow Award

2021 – Hatch Capital Exercise Award

2021 – DIH Equipment Dairy Hub award (Co-PI)

2019 – Honorary Research Assistant professor, Department of Animal Science,
University of Wisconsin-Madison

2018 – Wyoming AES Outstanding Young Scientist Award 

2017 – NIH IDeA Western Regional Conference Session Chair-Las Vegas, NV  

2016 – Wyoming INBRE Bioinformatics Program Award 

2015 – Outstanding Poster Presentation Award in the China-USA Cardiovascular Symposium at AHA Scientific Conference-Orlando, FL  

2014 – Young Investigator Outstanding Presentation Award in the ACRE/CNAHA Cardiovascular Research Symposium at AHA Scientific Conference-Chicago, IL 

2014 – Xi-an International Cardiovascular Forum and the 19th Xijing-Mayo clinic cardiovascular symposium session chair-Xi’an, China 

2011- 2013 – Honorary fellow at Department of Animal Science at UW-Madison

2012 – Abstract and Oral presentation Award for Excellence at International Meeting of Myofilament Protein Function-Madison, WI 

Wei Guo, Marion Greaser, Michael Gotthardt, Norbert Hubner, (equally contribution). polynucleotides for diagnostic and prognostic of a cardiac disease. European Patent: application #: 10736605.6-1222/ Patent #: EP2446059