Wei Guo

Selected Peer-Reviewed Articles

Methawasin M, Meinke S, Radke MH, Farman GP, Hourani Z, Smith JE  3rd, Guo W, Granzier H, Gotthardt M. Rbm20 antisense oligonucleotides alleviate diastolic dysfunction in a mouse model of cardiometabolic heart failure (HFpEF). Cardiovasc Res. 2025; cvaf171. doi: 10.1093/cvr/cvaf171.

Methawasin M#, Zhang YH#, Gregorich ZR, He YQ, Liu CL, Muldoon J, Hourani Z, Smith JE, Granzier H and Guo W*. Reducing granules without splicing restoration alleviates RBM20 cardiomyopathy. Circulation Research. 2025. 136(10): 1134-1146. (#co-first author). DOI: 10.1161/CIRCRESAHA.124.324781

Ge, W., Wang, Q., Tao, J., Ford, S. P., Guo, W., Wang, X., & Ren, J. Maternal Nutrient Restriction Confers Myocardial Remodeling in Association with Dampened Autophagy and Mitophagy in Adult Sheep Offspring. International Journal of Drug Discovery and Pharmacology. 2025, 4(1), 100003. doi: https://doi.org/10.53941/ijddp.2025.100003

Bordbar, F., Guo, W., Wadood, A. A., & Nie, Q. Skeletal muscle myopathies and cardiovascular diseases in poultry: challenges for meat production. World’s Poultry Science Journal, 2025, 1–25. https://doi.org/10.1080/00439339.2025.2506400

Velleman SG, Guo W and Strasburg GM. Editorial: The effect of muscle pathogenesis on avian physiology, animal welfare, and quality of muscle as a food. Front. Physiol. 2025. 16:1577465. doi: 10.3389/fphys.2025.1577465

Zhu CQ, Bishop T, Gregorich ZR and Guo W*. Titin is a new factor regulating arterial stiffness through vascular smooth muscle cell tone in male rats. Physiological Reports. 2025. 13(6): e70270. doi: 10.14814/phy2.70270

Gregorich ZR and Guo W*. Alternative splicing factors and cardiac disease: more than just mis-splicing? RNA. 2025:rna.080332.124. doi: 10.1261/rna.080332.124.

Guo W, Velleman SG and Strasburg GM. From discovery to application: merging modern omics with traditional hypothesis-driven approaches in muscle myopathy studies. Front. Physiol. 2025. 15: 1520196. doi:10.3389/fphys.2024.1520196

Gregorich ZR, Larson EJ, Zhang Y, Braz CU, Liu C, Ge Y, Guo W*. Integrated proteomics and transcriptomics analysis reveals insights into differences in premature mortality associated with disparate pathogenic RBM20 variants. J Mol Cell Cardiol. 2024;S0022-2828(24)00173-1. DOI: 10.1016/j.yjmcc.2024.10.013.

Wei C, Niu Y, Chen B, Wang Y, Cai H, Han R, Tian Y, Liu X, Guo W*, Kang X, Li Z. Divergent regulatory roles of transcriptional variants of the chicken LDB3 gene in muscle shaping. J Agric Food Chem. 2024;72(21):12240-12250. DOI: 10.1021/acs.jafc.4c00520.

Gregorich ZR, Zhang Y, Kamp TJ, Granzier HL, Guo W*. Mechanisms of RBM20 cardiomyopathy: insights from model systems. Circ Genom Precis Med. 2024;17(1):e004355. DOI: 10.1161/CIRCGEN.123.004355.

Stroik D, Gregorich ZR, Raza F, Ge Y, Guo W*. Titin: roles in cardiac function and diseases. Front Physiol. 2024;15:1385821. DOI: 10.3389/fphys.2024.1385821.

Bayne EF, Rossler KJ, Gregorich ZR, Aballo TJ, Roberts DS, Chapman EA, Guo W, Palecek SP, Ralphe JC, Kamp TJ, Ge Y. Top-down proteomics of myosin light chain isoforms define chamber-specific expression in the human heart. J Mol Cell Cardiol. 2023; 181:89-97. DOI: 10.1016/j.yjmcc.2023.06.003.

Zhang Y#, Gregorich ZR#, Wang Y, Braz CU, Zhang J, Liu Y, Liu P, Shen J, Aori N, Hacker TA, Granzier H, Guo W*. Disruption of the nuclear localization signal in RBM20 is causative in dilated cardiomyopathy. JCI Insight. 2023; 8(13):e170001. DOI: 10.1172/jci.insight.170001. (Featured as Editors’ Picks; https://insight.jci.org/this-month/2023/8) (#co-first author)

Melby JA, Brown KA, Gregorich ZR, Roberts DS, Chapman EA, Ehlers LE, Gao Z, Larson EJ, Jin Y, Lopez JR, Hartung J, Zhu Y, McIlwain SJ, Wang D, Guo W, Diffee GM, Ge Y. High sensitivity top-down proteomics captures single muscle cell heterogeneity in large proteoforms. Proc Natl Acad Sci U S A. 2023;120(19):e2222081120. DOI: 10.1073/pnas.2222081120 

Selected Book Chapters

Guo Wei and Greaser, M.L. 2022. “Muscle Structure, Proteins and Meat Quality” in “New aspects of meat quality-from genes to ethics”, 2ed. Peter Purslow, Elsevier, Philadelphia, PA, In Press

Greaser, M.L. and Guo Wei. 2011. “Post-mortem Muscle Chemistry” In: “Handbook of Meat and Meat Processing, Second Edition”, ed. YH Hui, CRC Press, Boca Raton, FL, pp70-78. 

Greaser, M.L. and Guo Wei. 2014. “Proteins” In “Handbook of Muscle Foods Analysis, Second Edition”, ed, Leo M.L.Nollet, Fidel Toldra, CRC Press, Boca Raton, FL, PP357-368 

Guo Wei and Greaser, M.L. 2016. “Muscle Structure, Proteins and Meat Quality” in “New aspects of meat quality-from genes to ethics”, ed. Peter Purslow, Elsevier, Philadelphia, PA, PP13-32 

Selected Posters

Wei Guo, Zachery Gregrich, Yanghai Zhang. RBM20 cardiomyopathy: splicing and beyond. Caparica, Portugal, July 16th-20th 2023. Invited as oral presentation (Declined due to visa issue)

Yanghai Zhang, Zachery R. Gregorich, Yujuan Wang, Camila Urbano Braz, Jibin Zhang, Yang Liu, Peiheng Liu, Nanyumuzi Aori, Timothy A. Hacker, Henk Granzier, Wei Guo. Identification of the nuclear localization signal in RBM20 and its function in the pathogenesis of dilated cardiomyopathy. BCVS Scientific Meeting 2023. Boston, MA. July 30th-August 3rd, 2023.

Yanghai Zhang, Zachery R. Gregorich, Yujuan Wang, Camila Urbano Braz, Jibin Zhang, Yang Liu, Peiheng Liu, Nanyumuzi Aori, Timothy A. Hacker, Henk Granzier, Wei Guo. Disruption of RS domain function in RBM20 is causative in dilated cardiomyopathy. The 42nd International Society for Heart Research (ISHR)-North American Section (NAS) meeting, Madison, WI. June 27th – June 30th 2023. Selected as ECI oral presentation.

Yanghai Zhang, Zachery R. Gregorich, Eli J. Larson, Ying Ge, Wei Guo. Proximity labeling proteomics uncovers mechanism of disrupted RBM20 nuclear import in RBM20 cardiomyopathy. The 42nd International Society for Heart Research (ISHR)-North American Section (NAS) meeting, Madison, WI. June 27th – June 30th 2023. Selected as an oral presentation at ACRE-ISHR pre-conference symposium.

Zachery R. Gregorich, Yanghai Zhang, Kavish H. Khinsar, Mohammad Abdullah Khan, Camila Urbano Braz, Yang Liu, Timothy A. Hacker, Henk Granzier, Wei Guo. Loss of key nuclear localization sequence element in the RBM20 RS domain causes DCM. American Heart Association Scientific Session 2022. Chicago, IL. November 5th to 7th, 2022.

Zachery R. Gregorich, Eli J. Larson, Yanghai Zhang, Ying Ge, Wei Guo. Insights into RBM20 cardiomyopathy revealed by global proteomics. BCVS Scientific Meeting 2022. Chicago, IL. July 25th-28th, 2022.

Wei Guo, Zachery Gregorich and Yanghai Zhang. Role of SR protein RBM20 in the pathogenesis of heart failure. 3rd Global Virtual Conference on Cardiology. July 11th to 12th, 2022. Selected as an oral presentation.

Jeffrey Gao and Wei Guo. RBM20 regulates muscle hypertrophy through titin and calcium signaling. Experimental Biology meeting. Philadelphia, PA, April 2nd to 5th, 2022

Zachery R. Gregorich, Yanghai Zhang, Kavish H. Khinsar, Mohammad Abdullah Khan, Camila Urbano Braz, Yang Liu, Timothy A. Hacker, Henk Granzier, Wei Guo. Disruption of the nuclear localization signal (NLS) in the RS domain of RBM20 is causative in dilated cardiomyopathy. Myofilament Meeting. Madison, WI. May 21st to 24th, 2022.

Eli J. Larson, Yanghai Zhang, Chunyan Wang, Chaoqun Zhu, Zhiyong Yin, Brad Li, Timothy J. Aballo, Jake A. Melby, Ying Ge and Wei Guo. RNA binding motif 20 regulation of cardiac metabolic associated proteins identified through global quantitative proteomics. Biophysical Society meeting, Berlin, Germany, Virtual, November 29th, 2021. Selected as an oral presentation.

Yanghai Zhang, Chunyan Wang, Mei Methawasin, Camila Urbano Braz, Jeffrey Gao-Hu, Betty Yang, Joshua Strom, Timothy Hacker, Hasan Khatib, Henk Granzier and Wei Guo. Gain-of-function mutations in Rbm20 result in cardiac remodeling and pathogenesis in mice. AHA Scientific meeting, Boston, MA, Virtual, November 13th to 15th, 2021. Selected as an oral presentation.

Chunyan Wang, Yanghai Zhang, Jeffery Gao, Chao Yang and Wei Guo. Ribonucleoprotein (RNP) aggregation promotes high mortality rate at younger age in RBM20 mutation knock-in mice. The 4th International Caparica Conference in Splicing, Caparica, Portugal, July 26th-29th 2021. Selected as an oral presentation.

Chunyan Wang, Yanghai Zhang, Mei Methawasin, Camila Urbano Braz, Jeffrey Gao-Hu, Betty Yang, Joshua Strom, Timothy Hacker, Hasan Khatib, Henk Granzier and Wei Guo. RBM20 mutation is a high genetic risk factor for premature death through RNA-protein condensates in mice. 40th Annual Conference of the North American Section (NAS) of the International Society of Heart Research (ISHR), Denver, CO, September 13th to 16th, 2021.

Yanghai Zhang, Chunyan Wang, Jeffery Gao, Chaoyang and Wei Guo. RBM20 mutations in RS domain promote heart failure and premature death at younger age. World Biological Science and Technology Conference, Virtual meeting. August 25th to 27th, 2021. Selected as an oral presentation.

Wei Guo, Mingming Sun, Yutong Jin, Martin Liss, Michael Gotthardt, Mei Methawasin, Henk L. Granzier and Ying Ge. Phosphorylation of RBM20 on RS Domain Plays A Key Role in The Development of Heart Failure. The 3rd –international Caparica Conference in Splicing, Caparica, Portugal, July 13th-16th 2020. Selected as an oral presentation.