Hasan Khatib

Selected Peer-Reviewed Articles

Townsend J, Kizilaslan M, Kizilaslan Z, Taylor T, Khatib H*. 2025. Epigenetic remodeling of sheep oocytes and embryos induced by maternal methionine supplementation. Epigenetics. 2025 Dec;20(1):2567459. doi: 10.1080/15592294.2025.2567459. Epub 2025 Sep 29. PMID: 41024457.

Kizilaslan M, Braz CU, Townsend J, Taylor T, Crenshaw TD, Khatib H*. 2025. Transgenerational Epigenetic and Phenotypic Inheritance Across Five Generations in Sheep. Int J Mol Sci. ;26(13):6412. doi: 10.3390/ijms26136412. PMID: 40650189.

Townsend J, Gross N, Peng Z, Peñagaricano F, Yang Z, Ahsan N, Khatib H*. 2025. The embryonic DPPA3 gene stimulates the expression of pregnancy-related genes in bovine endometrial cells. J Dairy Sci. 108(6):6471-6487. doi: 10.3168/jds.2024-25872. Epub 2025 Apr 11. PMID: 40222672.

Townsend J, Peng Z, Kizilaslan M, Taylor T, Yang Z, Ahsan N, Khatib H*. 2025. Methionine supplementation-induced alteration of sheep seminal plasma miRNAs and proteome. J Anim Sci. 103:skaf192. doi: 10.1093/jas/skaf192. PMID: 40495297; PMCID: PMC12246824.

Li F, Zhang Y, Zhan T, Sui M, Ge W, Khatib H, and Wang X. 2024. Single-cell ATAC-seq of early murine skin development reveals regulatory programs underlying placode and dermal condensate cell fate commitment. Animal Research and One Health, 1– 19. https://doi.org/10.1002/aro2.99

Kalbfleisch TS, McKay SD, Murdoch BM, Adelson DL, Almansa-Villa D, Becker G, Beckett LM, Benítez-Galeano MJ, Biase F, Casey T, Chuong E, Clark E, Clarke S, Cockett N, Couldrey C, Davis BW, Elsik CG, Faraut T, Gao Y, Genet C, Grady P, Green J, Green R, Guan D, Hagen D, Hartley GA, Heaton M, Hoyt SJ, Huang W, Jarvis E, Kalleberg J, Khatib H, Koepfi KP, Koltes J, Koren S, Kuehn C, Leeb T, Leonard A, Liu GE, Low WY, McConnell H, McRae K, Miga K, Mousel M, Neibergs H, Olagunju T, Pennell M, Petry B, Pewsner M, Phillippy AM, Pickett BD, Pineda P, Potapova T, Rachagani S, Rhie A, Rijnkels M, Robic A, Rodriguez Osorio N, Safonova Y, Schettini G, Schnabel RD, Sirpu Natesh N, Stegemiller M, Storer J, Stothard P, Stull C, Tosser-Klopp G, Traglia GM, Tuggle CK, Van Tassell CP, Watson C, Weikard R, Wimmers K, Xie S, Yang L, Smith TPL, O’Neill RJ, Rosen BD. 2024. The Ruminant Telomere-to-Telomere (RT2T) Consortium. Nat Genet. 56(8):1566-1573. doi: 10.1038/s41588-024-01835-2.

Braz UB, Passamonti M, Khatib H. 2024. Characterization of genomic regions escaping epigenetic reprogramming in sheep. Environmental Epigenetics, 2024, 10(1), 1–12. DOI: https://doi.org/10.1093/eep/dvad010

Strangstalien A, Braz CU, Miyamoto A, Marey M, Khatib H. 2024. Early transcriptomic changes in peripheral blood 7 days post-embryo transfer in dairy cattle. J Dairy Sci. 107, 5:3080-3089.

Laporta J, Khatib H, Zachut M. 2024. Phenotypic and molecular evidence of inter-generational effects of heat stress in livestock species and humans. Animal 29:101121. doi: 10.1016/j.animal.2024.101121.

Khatib H, Townsend J, Konkel MA, Conidi G, Hasselkus JA. 2024. Calling the question: what is mammalian transgenerational epigenetic inheritance? Epigenetics (1):2333586. doi: 10.1080/15592294.2024.2333586.

Namous H, Strillacci MG, Braz CU, Shanmuganayagam D, Krueger C, Peppas A, Soffregen WC, Reed J, Granada JF, Khatib H. 2023. ITGB2 is a central hub-gene associated with inflammation and early fibro-atheroma development in a swine model of atherosclerosis. Atheroscler Plus. 2023 Nov 15;54:30-41.

Namous H, Krueger C, Cheng Y, Melo PHC, Peppas P, Kaluza GL, Stoffregen WC, Reed J, Khatib H, Granada JF. 2023. Longitudinal dynamics of Circulating miRNAs in a Swine Model of Familial Hypercholesterolemia during Early Atherosclerosis. Sci Rep. 2023 Nov 7;13(1):19355. doi: 10.1038/s41598-023-46762-0.

Townsend J, Braz CU, Taylor T, Khatib H. 2023. Effects of paternal methionine supplementation on sperm DNA methylation and embryo transcriptome in sheep. Environmental epigenetics, 9(1), dvac029. https://doi.org/10.1093/eep/dvac029

Lihua Liu, Bing Sun, Fan Zhang, Zhenyu Zhong, Yuelang Zhang, Fang Li, Hasan Khatib, and Xin Wang. 2022. LncRNA MPFAST Promotes Proliferation and Fatty Acids Synthesis of Bovine Mammary Epithelial Cell by Sponging miR-103 Regulating PI3K-AKT Pathway. Journal of Agricultural and Food Chemistry. (accepted).

Namous H, Braz CU, Wang Y and Khatib H. 2022 The Activation of Protamine one Using Epigenome Editing Decreases the Proliferation of Tumorigenic Cells. Front. Genome Ed. 4:844904. doi: 10.3389/fgeed.2022.844904

Selected Book Chapters

Ibeagha-Awemu EM and Khatib H (2017) Epigenetics of Livestock Breeding. Handbook of Epigenetics: The New Molecular and Medical Genetics. Edited by: Trygve Tollefsbol. Elsevier Science Publishing Co Inc, pp. 441-457. ISBN: ISBN: 9780128053881

Khatib H (Editor) Molecular and Quantitative Animal Genetics. Wiley-Blackwell, Oxford, UK. (2015).

Khatib H (Editor)(2012). Livestock Epigenetics. Wiley-Blackwell, Oxford, UK.

Coordinator of the special issue “Morris Soller: Energizing Animal Breeding & Genetics”. Animal Genetics 43, Issue Supplement s1, Pages 1–113 (2012)

Driver A, Huang W, and Khatib H (2012). Roles of Imprinted Genes in Fertility and Promises of the Genome-Wide Technologies. Livestock Epigenetics. Wiley-Blackwell, Oxford, UK, pp. 43-57

Bagnato A, Khatib H, Ajmone-Marsan P, Schiavini F, Lipkin E (2007). Achievements of research in the field of molecular genetics – Recent advance and perspectives in cattle genome discovery and in application of genomic selection to breeding plans. In WAAP book of the year 2006, Animal production and Animal Science Worldwide. Wageningen Academic Publishers, The-Netherlands

Gruenbaum Y, Frumkin A, Rangini Z, Revel E, Yarus S, Margalit Y, Khatib H, Darvasi A, and Fainsod A (1993). Chox-cad Characterization and Rooster Sperm Preservation as a First Step in the Generation of Transgenic Chickens with Modified Homeobox Genes in: Manipulation of The Avian Genome. CRC Press, pp. 151-164.

Selected Conference Proceedings

Jessica Townsend, Camila U. Braz, Todd Taylor, Hasan Khatib. Effects of paternal methionine supplementation on sperm DNA methylation and embryo transcriptome in sheep. The International Plant and Animal Genome Conference. January 12-17, 2023, San Diego, USA

Hadjer Namous, Hasan Khatib. Transcriptome profiling of atherosclerotic lesions in abdominal aortic tissues using Wisconsin Miniature Swine of familial hypercholesterolemia. Swine Biomedial Conference June 2023.

Hadjer Namous, Hasan Khatib. Genes and Pathways Involved in Fibro-Atheroma Development in an Atherosclerosis Swine Mode. The International Plant and Animal Genome Conference. January 12-17, 2023, San Diego, USA

Camila Braz, Hasan Khatib. Effects of Paternal Diet on DNA Methylation and Phenotypes of Next Generations in Sheep. The International Plant and Animal Genome Conference. January 12-17, 2023, San Diego, USA

Yanghai Zhang, Chunyan Wang, Mei Methawasin, Camila Urbano Braz, Jeffrey Go-Hu, Betty Yang, Joshua Strom, Timothy Hacker, Hasan Khatib, Henk Granzier and Wei Guo. Gain-of-function mutations in Rbm20 result in cardiac remodeling and pathogenesis in mice. AHA Scientific meeting, Boston, MA, Virtual, November 13 to 15th, 2021.

Chunyan Wang, Yanghai Zhang, Mei Methawasin, Camila Urbano Braz, Jeffrey Gao-Hu, Betty Yang, Joshua Strom, Timothy Hacker, Hasan Khatib, Henk Granzier and Wei Guo. RBM20 mutation is a high genetic risk factor for premature death through RNA-protein condensates in mice. 40th Annual Conference of the North American Section (NAS) of the International Society of Heart Research (ISHR), Denver, CO, September 13 to 16th, 2021.

Khatib H and Namous H. Integrative analysis of methylomic and transcriptomic data in fetal sheep muscle tissues in response to maternal diet during pregnancy. International Society of Animal Genetics Meeting (ISAG), Dublin, Ireland July 13, 2017.

Chikri M, Khatib H, Abou-Samra A, and Abdulghani M. Characterization of Circulating miRNAs in Insulin Sensitive and Insulin Resistant Arab Individuals in Qatar. March 21, 2016. Qatar Foundation Annual Research Conference, Doha, Qatar

Milo Wiltbank M, Carvalho P, Souza A, Fricke P, Toledo M, Sartori R, Santos J, Pontes G, Luchini D, Peñagaricano F, Khatib H, Hackbart K, and Shave R. Potential benefits of nutrition on reproductive performance of high-efficiency dairy cows. July 16, 2015. JAM meeting, Orlando, Florida.

Peñagaricano F, Valente BD, Steibel JP, Bates RO, Ernst CW, Khatib H, and Rosa GJM. Exploring causal networks underlying fat deposition and muscularity in pigs through the integration of phenotypic, genotypic and transcriptomic data. JAM meeting, July 12-16, 2015. Orlando, Florida.

Kropp J and Khatib H. Non-Invasive Biomarkers of Embryo Development in Cattle. Plant & Animal Genome meeting (PAG) XXIII, San Diego, CA. January 12, 2015.

F. Peñagaricano, B.D. Valente, J.P. Steibel, R.O. Bates, C.W. Ernst, H. Khatib and G.J.M. Rosa. Searching for Causal Networks Involving Latent Variables in Complex Traits: An Application to Growth, Carcass, and Meat Quality Traits in Pig. 10th World Congress on Genetics Applied to Livestock Production. Canada, Vancouver, 17 – 22 August 2014.

Peñagaricano F, Guilherme J. M. Rosa GJM, Radunz A, and Khatib H. 2014. Effect of Maternal Nutrition on the Transcriptome of Fetal Muscle in Sheep. The Plant & Animal Genome XXII Conference, January 11-14, 2014; San Diego, CA.

Peñagaricano F, Souza AH, Carvalho PD, Driver AM, Gambra R, Kropp J, Hackbart KS, Luchini D, Shaver RD, Wiltbank MC, and Khatib H. 2013. Nutritional genomics: effect of maternal methionine supplementation on the transcriptome of day 7 embryos from superovulated lactating dairy cows. ADSA®-ASAS Joint Annual Meeting, Indianapolis – USA. July 2013.

Lan X, Gambra R, Berg MA, Cretney EJ, Khatib H, and Radunz AE. 2012. Maternal dietary energy source during gestation affects expression of imprinted genes in fetal tissues in sheep. ADSA®-ASAS Joint Annual Meeting, Phoenix, AZ July 15-July 20.

Selected Presentations

Sheep: the first animal model to investigate the brain-sperm connection. International Sheep Genomics Consortium workshop, The Plant and Animal Genome Meeting, San Diego, CA, USA. January 13, 2025.

The Impact of the environment on our genome. Department of Animal Sciences, Purdue University. February 19, 2025.

Environmental Epigenetics: Darwin vs. Lamarck. Domestic Animal DOHAD and Epigenetics Webinar. May 27, 2025.

The Role of Epigenetics in Sustainable Agriculture: Environmental Applications and Insights (virtual presentation). Department of Animal Production Science and Technology, IPB University, Indonesia. July 30, 2025.

The Role of Epigenetics in Sustainable Agriculture. 2025 International Conference on Beef Cattle Improvement and Industrialization (virtual presentation), Xian, China. November 3, 2025

Inheritance Beyond DNA: Exploring the Impact of the Environment on Epigenetic Modifications. Department of Animal Science, UC Davis, USA. May 6, 2024

What is transgenerational epigenetic inheritance? The Plant and Animal Genome Meeting, San Diego, CA, USA. January 12, 2024

The Epigenetics Revolution: How Epigenetics Links Environment and Genes in Animals. Sultan Qaboos University, College of Agricultural and Marine Sciences. Muscat, Oman. January 28, 2024

Epigenetic applications in agriculture. “The 1st international conference on recent trends in improving resistance against diseases using molecular genetics and omics tools. Abdul Wali Khan University Mardan, Pakistan. December 6-7, 2023

Epigenetics Applications in Animal Breeding. The 2023 National Breeders Roundtable. St. Louis, Missouri, USA. October 25, 2023

Environmental epigenomics and transgenerational epigenetic inheritance in livestock and shellfish species. The 115th Annual Meeting of the National Shellfisheries Association, Baltimore, Maryland, USA. March 30, 2023.

Epigenetics and the Gene-Environment Interaction Connection: What We’ve Learned. Gordon Research Conference, Quantitative Genetics and Genomics. Ventura, CA, USA. February 13, 2023

Transgenerational epigenetics inheritance in sheep. The 2023 VEERkracht Dairy Congress. The Netherlands. January 30, 2023.

Effects of paternal nutrition on the epigenome and phenotypes of the offspring. The 2022 Aspen Perinatal Biology Symposium. Aspen, Colorado, USA. August 28-31, 2022.

Environmental Epigenetics and transgenerational epigenetic inheritance. First International Symposium on ONE HEALTH Epigenomes and Microbiomes: From Soil to People. Quito, Ecuador. September 13, 2022.