1675 Observatory Dr
546 Animal Sciences
Madison, WI 53706
Dairy cattle breeding for improved milk production traits in cattle. US 20070015164 A1. Publication date: January 18, 2007
Detection of Lethality Gene for Improved Fertility in Mammals. US 20070234437 A1. Publication date: October 4, 2007
Dairy cattle breeding for improved milk production traits in cattle. US 20080307535 A1. Publication date: December 11, 2008
Methods and compositions for improved cattle longevity and milk production. WO 2009062042 A3. Publication date: August 27, 2009
Methods and Compositions for Testing and Breeding Cattle for Improved Fertility and Embryonic Survival. US 20100185047 A1. Publication date: July 22, 2010
Methods and compositions for genetically detecting improved milk production traits in cattle
Hasan Khatib is a professor of genetics and epigenetics. He earned his BS in Biology, MS in Human Genetics, and Ph.D.in Genetics from the Hebrew University of Jerusalem. Afterward, he worked in the Department of Genetics at the Hebrew University as a post-doctoral fellow and as a research scientist.
Dr. Khatib currently has over 100 peer-reviewed publications in the areas of embryonic development, male fertility, production traits, epigenetics, and nutritional epigenetics. His papers have appeared in the BMC Genomics, PloS one, Science, Genome Research, Animal Genetics, Journal of Dairy Science, Journal of Animal Science, Mammalian Genome, Epigenetics and other journals.
His research focuses on understanding the contributions of epigenetics to production, reproduction, and health traits. More specifically, his research examines the transgenerational epigenetic effects of paternal and maternal nutrition on phenotypes of the next generations in livestock. His group recently demonstrated that DNA methylation patterns in the sperm were affected by a paternal diet and were transgenerationally inherited by subsequent generations in sheep. He is also interested in identifying epigenetic markers as predictors of embryo development and fertility using non-invasive methods. Research methods used in his lab include embryo production, transcriptomics, whole-genome bisulfite sequencing, cell culture, gene editing, and epigenome editing. Dr. Khatib is the editor of the books “Livestock Epigenetics” and “Molecular and Quantitative Animal Genetics.
Selected Peer-Reviewed Articles
Lihua Liu, Bing Sun, Fan Zhang, Zhenyu Zhong, Yuelang Zhang, Fang Li, Hasan Khatib*, and Xin Wang. 2022. LncRNA MPFAST Promotes Proliferation and Fatty Acids Synthesis of Bovine Mammary Epithelial Cell by Sponging miR-103 Regulating PI3K-AKT Pathway. Journal of Agricultural and Food Chemistry. (accepted).
Namous H, Braz CU, Wang Y and Khatib H*. 2022 The Activation of Protamine one Using Epigenome Editing Decreases the Proliferation of Tumorigenic Cells. Front. Genome Ed. 4:844904. doi: 10.3389/fgeed.2022.844904
Braz CU, Taylor T, Namous H, Townsend J, Crenshaw T, Khatib H*. 2022. Paternal diet induces transgenerational epigenetic inheritance of DNA methylation signatures and phenotypes in sheep model. PANS-Nexus, Volume 1, Issue 2, May 2022, pgac040, https://doi.org/10.1093/pnasnexus/pgac040
Zhang YH, Wang CY, Sun MM, Jin YT, Braz C, Khatib H, Hacker T, Liss M, Gotthardt M, Granzier H, Ge Y and Guo W. 2022. RBM20 phosphorylation and its role in nucleocytoplasmic transport and cardiac pathogenesis. FASEB 36 (5): e22302.
Errafii K, Hassoun S, Alkasem M, Jayyous A, Arredouani A, Khatib H, Azizi F, Dehbi M, Mohammad RM, Abdul-Ghani M, Chikri M. 2022. Comprehensive analysis of circulating miRNA expression profiles in insulin resistance in Qatari population. All Life 15:1, 191-202.
Wang C, Zhang Y, Methawasin M, Braz CU, Gao-Hu J, Yang B, Strom J, Gohlke J, Hacker T, Khatib H, Granzier H, Guo W. 2022. RBM20S639G mutation is a high genetic risk factor for premature death through RNA-protein condensates. J Mol Cell Cardiol. 165:115-129. [1, 2]
Amiri Roudbar M, Mousavi SF, Ardestani SS, Brito Lopes F, Momen M, Gianola D, Khatib H*. 2021. Prediction of biological age and evaluation of genome-wide dynamic methylomic changes throughout human aging. G3 (Bethesda) 11(7):jkab112.
Kusama K, Rashid MB, Kowsar R, Marey MA, Talukder AK, Nagaoka K, Shimada M, Khatib H, Imakawa K, Miyamoto A. 2021. Day 7 Embryos Change the Proteomics and Exosomal Micro-RNAs Content of Bovine Uterine Fluid: Involvement of Innate Immune Functions. Front Genet. 2021;12:676791.
Khatib H*. 2021. Transgenerational epigenetic inheritance in farm animals: How substantial is the evidence?. Livestock Science 250, 104557, https://doi.org/10.1016/j.livsci.2021.104557.
Gross N, Taylor T, Crenshaw T, Khatib H*. 2020. The Intergenerational Impacts of Paternal Diet on DNA Methylation and Offspring Phenotypes in Sheep. Front. Genet., 11:597943. doi: 10.3389/fgene.2020.597943. eCollection 2020. 11. Gross N, Peñagaricano F, Khatib H*. 2020. Integration of whole-genome DNA methylation data with RNA sequencing data to identify markers for bull fertility. Anim Genet. 51(4):502-510.[1, 3] 12. Gross N, Strillacci MG, Peñagaricano F, Khatib H*. 2019. Characterization and functional roles of paternal RNAs in 2-4 cell bovine embryos. Sci Rep. 9(1):20347.
Jiao BL, Zhang XL, Wang SH, Wang LX, Luo ZX, Zhao HB, Khatib H, and X. Wang X. 2019. The MicoRNA-221 Regulates Proliferation of Bovine Mammary Gland Epithelial Cells by Targeting the STAT5a and IRS1 Genes. Dairy Sci. 102(1):426-435.
Giuffra E, Tuggle CK; The FAANG Consortium. 2019. Functional Annotation of Animal Genomes (FAANG): Current Achievements and Roadmap. Annu Rev Anim Biosci. 7:65-88.
Khatib H*, Gross N. 2019. Embryo survival: a genomic perspective of the other side of fertility. J Dairy Sci. 102:3744–3753.
Selected Book Chapters
Ibeagha-Awemu EM and Khatib H (2017) Epigenetics of Livestock Breeding. Handbook of Epigenetics: The New Molecular and Medical Genetics. Edited by: Trygve Tollefsbol. Elsevier Science Publishing Co Inc, pp. 441-457. ISBN: ISBN: 9780128053881
Khatib H (Editor) Molecular and Quantitative Animal Genetics. Wiley-Blackwell, Oxford, UK. (2015).
Khatib H (Editor)(2012). Livestock Epigenetics. Wiley-Blackwell, Oxford, UK.
Coordinator of the special issue “Morris Soller: Energizing Animal Breeding & Genetics”. Animal Genetics 43, Issue Supplement s1, Pages 1–113 (2012)
Driver A, Huang W, and Khatib H (2012). Roles of Imprinted Genes in Fertility and Promises of the Genome-Wide Technologies. Livestock Epigenetics. Wiley-Blackwell, Oxford, UK, pp. 43-57
Bagnato A, Khatib H, Ajmone-Marsan P, Schiavini F, Lipkin E (2007). Achievements of research in the field of molecular genetics – Recent advance and perspectives in cattle genome discovery and in application of genomic selection to breeding plans. In WAAP book of the year 2006, Animal production and Animal Science Worldwide. Wageningen Academic Publishers, The-Netherlands
Gruenbaum Y, Frumkin A, Rangini Z, Revel E, Yarus S, Margalit Y, Khatib H, Darvasi A, and Fainsod A (1993). Chox-cad Characterization and Rooster Sperm Preservation as a First Step in the Generation of Transgenic Chickens with Modified Homeobox Genes in: Manipulation of The Avian Genome. CRC Press, pp. 151-164.
Effects of paternal nutrition on the epigenome and phenotypes of the offspring. The 2022 Aspen Perinatal Biology Symposium. Aspen, Colorado. August 28-31, 2022.
Nature vs. nurture: what do we inherit from our parents? The Department of Animal Sciences, University of Maryland, USA. April 13, 2021
The effects of paternal nutrition on traits and epigenomes of the next generations in sheep. The Plant and Animal Genome Meeting, San Diego, CA, USA. January 12, 2020
Transgenerational Epigenetic Inheritance: How Strong is the Evidence? 37th International Society for Animal Genetics Conference. Universitat de Lleida, Spain, July 11, 2019
Transgenerational Epigenetic Effects of Nutrition. Michigan State University, USA, May 7, 2019
Genetics and Epigenetics of male fertility. Erciyes University, Kayseri, Turkey, March 6, 2019
Does diet affect the traits of the next generations? Erciyes University, Kayseri, Turkey, March 7, 2019
The Identification of Biomarkers for Atherosclerosis using the Rapacz Swine The Plant and Animal Genome Meeting, San Digo, CA, USA, January 11, 2019.
Embryo survival: the other side of fertility; a genomic perspective. American Dairy Science Association meeting. Knoxville, Tennessee, USA, June 26, 2018.
Effects of maternal diet on traits of the next generations. Obihiro University of Agriculture and Veterinary Medicine. Obihiro, Japan, June 4, 2018.
The development of non-invasive biomarkers for embryo development and male fertility. Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan, June 8, 2018.
Series of lectures on molecular genetics and molecular techniques applications in agricultural research, Universidad Nacional Toribio Rodríguez de Mendoza (UNTRM), Chachapoyas, Peru, December 2-9, 2017
Applications of epigenetics in human health and animal production. The University of Milan, Italy, November 27, 2017.
Applications of Epigenetics in Fertility Research. Bioinformatics Institute, Denmark Technical University, Denmark, November 10, 2017.
Epigenetic signatures of early embryonic development and fertility in cattle. The Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany, November 6, 2017.
AN SCI/DY SCI 361 – Introduction to Animal and Veterinary Genetics (2 credits, Spring)
Course Description: The molecular basis for inheritance of monogenic and polygenic traits related to animal disease and production. An introduction to the principles of improving animal health and performance by selection and mating systems in companion animals, horses, livestock, and poultry.
Requirements: Genetics 160 or 466 or con reg course in statistics.
AN SCI/DY SCI 362 – Veterinary Genetics (2 credits, Spring)
Course Description: The genetic basis for predisposition to disease or resistance to disease in livestock and companion animal species. Genetic defects, their discovery, diagnosis and treatment.
Requirements: Dy Sci/AN SCI/DY SCI 361; or Genetics 160 or 466 Zool/Bot 152
AN SCI 435 – Animal Sciences Proseminar (2 credits, Fall)
Course Description: Methods of assessing information quality are studied. Each student develops an analytical and critical seminar on a topic of personal interest in the animal sciences.
Requirements: Senior Standing
CALS Facilities Committee
Animal and Dairy Sciences Climate and Diversity Committee
Animal and Dairy Sciences Undergraduate Curriculum Committee
Organizer and Chair of the Animal Epigenetics workshop; Plant & Animal Genome Meeting, San Diego, CA
Organizer of the Animal Epigenetics Workshop; International Society of Animal Genetics Meeting
Review Editor, Frontiers in Genetics