Hasan Khatib

Selected Peer-Reviewed Articles

Lihua Liu, Bing Sun, Fan Zhang, Zhenyu Zhong, Yuelang Zhang, Fang Li, Hasan Khatib*, and Xin Wang. 2022. LncRNA MPFAST Promotes Proliferation and Fatty Acids Synthesis of Bovine Mammary Epithelial Cell by Sponging miR-103 Regulating PI3K-AKT Pathway. Journal of Agricultural and Food Chemistry. (accepted).

Namous H, Braz CU, Wang Y and Khatib H*. 2022 The Activation of Protamine one Using Epigenome Editing Decreases the Proliferation of Tumorigenic Cells. Front. Genome Ed. 4:844904. doi: 10.3389/fgeed.2022.844904

Braz CU, Taylor T, Namous H, Townsend J, Crenshaw T, Khatib H*. 2022. Paternal diet induces transgenerational epigenetic inheritance of DNA methylation signatures and phenotypes in sheep model. PANS-Nexus, Volume 1, Issue 2, May 2022, pgac040, https://doi.org/10.1093/pnasnexus/pgac040

Zhang YH, Wang CY, Sun MM, Jin YT, Braz C, Khatib H, Hacker T, Liss M, Gotthardt M, Granzier H, Ge Y and Guo W. 2022. RBM20 phosphorylation and its role in nucleocytoplasmic transport and cardiac pathogenesis. FASEB 36 (5): e22302.

Errafii K, Hassoun S, Alkasem M, Jayyous A, Arredouani A, Khatib H, Azizi F, Dehbi M, Mohammad RM, Abdul-Ghani M, Chikri M. 2022. Comprehensive analysis of circulating miRNA expression profiles in insulin resistance in Qatari population. All Life 15:1, 191-202.

Wang C, Zhang Y, Methawasin M, Braz CU, Gao-Hu J, Yang B, Strom J, Gohlke J, Hacker T, Khatib H, Granzier H, Guo W. 2022. RBM20S639G mutation is a high genetic risk factor for premature death through RNA-protein condensates. J Mol Cell Cardiol. 165:115-129. [1, 2]

Amiri Roudbar M, Mousavi SF, Ardestani SS, Brito Lopes F, Momen M, Gianola D, Khatib H*. 2021. Prediction of biological age and evaluation of genome-wide dynamic methylomic changes throughout human aging. G3 (Bethesda) 11(7):jkab112.

Kusama K, Rashid MB, Kowsar R, Marey MA, Talukder AK, Nagaoka K, Shimada M, Khatib H, Imakawa K, Miyamoto A. 2021. Day 7 Embryos Change the Proteomics and Exosomal Micro-RNAs Content of Bovine Uterine Fluid: Involvement of Innate Immune Functions. Front Genet. 2021;12:676791.

Khatib H*. 2021. Transgenerational epigenetic inheritance in farm animals: How substantial is the evidence?. Livestock Science 250, 104557, https://doi.org/10.1016/j.livsci.2021.104557.

Gross N, Taylor T, Crenshaw T, Khatib H*. 2020. The Intergenerational Impacts of Paternal Diet on DNA Methylation and Offspring Phenotypes in Sheep. Front. Genet., 11:597943. doi: 10.3389/fgene.2020.597943. eCollection 2020.[1] 11.  Gross N, Peñagaricano F, Khatib H*. 2020. Integration of whole-genome DNA methylation data with RNA sequencing data to identify markers for bull fertility. Anim Genet. 51(4):502-510.[1, 3]  12.  Gross N, Strillacci MG, Peñagaricano F, Khatib H*. 2019. Characterization and functional roles of paternal RNAs in 2-4 cell bovine embryos. Sci Rep. 9(1):20347.

Jiao BL, Zhang XL, Wang SH, Wang LX, Luo ZX, Zhao HB, Khatib H, and X. Wang X. 2019. The MicoRNA-221 Regulates Proliferation of Bovine Mammary Gland Epithelial Cells by Targeting the STAT5a and IRS1 Genes. Dairy Sci. 102(1):426-435.

Giuffra E, Tuggle CK; The FAANG Consortium. 2019. Functional Annotation of Animal Genomes (FAANG): Current Achievements and Roadmap. Annu Rev Anim Biosci. 7:65-88.

Khatib H*, Gross N. 2019. Embryo survival: a genomic perspective of the other side of fertility. J Dairy Sci. 102:3744–3753.

Selected Book Chapters

Ibeagha-Awemu EM and Khatib H (2017) Epigenetics of Livestock Breeding. Handbook of Epigenetics: The New Molecular and Medical Genetics. Edited by: Trygve Tollefsbol. Elsevier Science Publishing Co Inc, pp. 441-457. ISBN: ISBN: 9780128053881

Khatib H (Editor) Molecular and Quantitative Animal Genetics. Wiley-Blackwell, Oxford, UK. (2015).

Khatib H (Editor)(2012). Livestock Epigenetics. Wiley-Blackwell, Oxford, UK.

Coordinator of the special issue “Morris Soller: Energizing Animal Breeding & Genetics”. Animal Genetics 43, Issue Supplement s1, Pages 1–113 (2012)

Driver A, Huang W, and Khatib H (2012). Roles of Imprinted Genes in Fertility and Promises of the Genome-Wide Technologies. Livestock Epigenetics. Wiley-Blackwell, Oxford, UK, pp. 43-57

Bagnato A, Khatib H, Ajmone-Marsan P, Schiavini F, Lipkin E (2007). Achievements of research in the field of molecular genetics – Recent advance and perspectives in cattle genome discovery and in application of genomic selection to breeding plans. In WAAP book of the year 2006, Animal production and Animal Science Worldwide. Wageningen Academic Publishers, The-Netherlands

Gruenbaum Y, Frumkin A, Rangini Z, Revel E, Yarus S, Margalit Y, Khatib H, Darvasi A, and Fainsod A (1993). Chox-cad Characterization and Rooster Sperm Preservation as a First Step in the Generation of Transgenic Chickens with Modified Homeobox Genes in: Manipulation of The Avian Genome. CRC Press, pp. 151-164.

Selected Presentations

Effects of paternal nutrition on the epigenome and phenotypes of the offspring. The 2022 Aspen Perinatal Biology Symposium. Aspen, Colorado. August 28-31, 2022.

Nature vs. nurture: what do we inherit from our parents? The Department of Animal Sciences, University of Maryland, USA. April 13, 2021

The effects of paternal nutrition on traits and epigenomes of the next generations in sheep. The Plant and Animal Genome Meeting, San Diego, CA, USA. January 12, 2020

Transgenerational Epigenetic Inheritance: How Strong is the Evidence? 37th International Society for Animal Genetics Conference. Universitat de Lleida, Spain, July 11, 2019

Transgenerational Epigenetic Effects of Nutrition. Michigan State University, USA, May 7, 2019

Genetics and Epigenetics of male fertility. Erciyes University, Kayseri, Turkey, March 6, 2019

Does diet affect the traits of the next generations? Erciyes University, Kayseri, Turkey, March 7, 2019

The Identification of Biomarkers for Atherosclerosis using the Rapacz Swine The Plant and Animal Genome Meeting, San Digo, CA, USA, January 11, 2019.

Embryo survival: the other side of fertility; a genomic perspective. American Dairy Science Association meeting. Knoxville, Tennessee, USA, June 26, 2018.

Effects of maternal diet on traits of the next generations. Obihiro University of Agriculture and Veterinary Medicine. Obihiro, Japan, June 4, 2018.

The development of non-invasive biomarkers for embryo development and male fertility. Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan, June 8, 2018.

Series of lectures on molecular genetics and molecular techniques applications in agricultural research, Universidad Nacional Toribio Rodríguez de Mendoza (UNTRM), Chachapoyas, Peru, December 2-9, 2017

Applications of epigenetics in human health and animal production. The University of Milan, Italy, November 27, 2017.

Applications of Epigenetics in Fertility Research. Bioinformatics Institute, Denmark Technical University, Denmark, November 10, 2017.

Epigenetic signatures of early embryonic development and fertility in cattle. The Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany, November 6, 2017.